Effects of Aspirin on Colorectal Cancer Related to Lynch Syndrome
نویسنده
چکیده
This article is a review of "Long-term effects of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial" by Burn et al. (2011), Lancet, 378, 2081-2087. For another perspective on the Burn et al. article as well as a discussion of challenges faced when interpreting a large prospective trial, please see the related article by Rita Wickham.
منابع مشابه
سندرم Lynch -l و گزارش شش مورد بیمار مبتلا
More than two decades ago, Henry T. Lynch reported a hereditary non polyposis colorectal cancer (HNPCC) which is seen in some families with dominant mode of inheritance, also know as Lynch Syndrome type I and II. This form to hereditary colorectal cancer has an early age of onset (Less than 45 years) with predominantly proximal colonic involvement (type I) and can also be associated with extrac...
متن کاملHereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies
Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various cancers, especially the uterine and colon cancers. The prevalence of this disease in the general population is about 1 in 500 and it causes about 2-3...
متن کاملEffect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome.
BACKGROUND Observational and epidemiologic data indicate that the use of aspirin reduces the risk of colorectal neoplasia; however, the effects of aspirin in the Lynch syndrome (hereditary nonpolyposis colon cancer) are not known. Resistant starch has been associated with an antineoplastic effect on the colon. METHODS In a randomized, placebo-controlled trial, we used a two-by-two design to i...
متن کاملAntiproliferative Effect of Aspirin on Colorectal Cancer Cell Line
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Aspirin may have anticancer properties, and can be effective as a novel strategy for the treatment of colorectal cancer (CRC). The aim of this study was to assess the cytotoxic effects of Aspirin drug in CRC cell lines compared with Oxaliplatin drug in vitro. Methods: Cell viability was assessed after treatment of SW742 and SW48...
متن کاملAspirin and Decreased Colon Cancer Risk: Challenges Interpreting a Large Prospective Trial
It is possible that your patients read the headline, “Aspirin may cut colon cancer risk by 60%,” published in USA Today in late October 2011, or that they saw a similar account on the Internet. This and other stories appeared the same day results of the CAPP2 trial (Burn et al., 2011) were reported in the medical literature. This study concluded that colorectal cancers (CRC) were significantly ...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2012